Human papillomavirus (HPV)

The researchers found that the cure rate for the 2 techniques were practically identical: rates of 64% and 54% were observed with optical maser vaporization and cryotherapy rewardively. The 10% difference amidst the two rates proved not to be statistically important.

Only the mastery rate observed with the combined lesions proved significantly different. Residual disease encountered after either laser vaporization or cryotherapy in patients with combined lesions was 37.0% and 78.9% respectively. This corresponded to an overall success rate of 40%.

Yliskoski et al. (1989) then examined the effects of the different therapies on the different types of HPV lesion (i.e., HPV6, 11, 16, 18, 31, and 33). They found, however, that the number of subjects in their study was too fine to draw whatsoever reliable conclusions in this regard.

Finally, they also noted that the cure rates achieved with both(prenominal) cryotherapy and laser manipulations were significantly higher(prenominal) than their observed rate of spontaneous turnaround. Therefore, the researchers concluded that either sermon will significantly alter the clinical rush of genital HPV infections. They also noted that, although cryotherapy and laser vaporization are both classified as destructive treatment modes, they can be employed as outpatient procedures; this makes them highly feasible (8:623).

The results of Yliskowsky et al. (1989) obviously stomach the application of C

Carmichael observed that regression to a nondysplastic state was 30.5% at six months, 50.4% at 1.5 years, 60.5% at 2.6 years, 70.9% at 3.5 years, and 77.3% at 4.5 years (2:591). Twentytwo patients had recurrence of minor degrees of cervical dysplasia and however 7.8% progressed to a greater degree (2:591). Furthermore, there was no occurrence of invasive cancer.

The photosensitizer, dihematoporphyrin ethers/esters (DHE) is cognize to selectively localize in tumors, thus allowing for the destruction of the tumor's cells. This identical mechanism has been shown to occur with HPVinfected cells in vivo: selective assemblage of a photosensitizer has allowed for the treatment of HPV infection while concomitantly sparing unobjectionable tissue.

These differences were found to be statistically nonsignificant. Moreover, when clinical efficacy was evaluated with respect to the different HPV types, no differences were observed either.

Thus, the doubleblind, placebocontrolled trial showed that, in contrast to previous studies, systemic IFNalpha has no significant effect on the outcome of genital HPV infections (7:58). Furthermore, although the IFNtreated separate showed a greater response against HPV16 at workweek 8, the number of patients in each subgroup was too small for any accurate analysis of the different HPV types.

These subjects were randomized into either a treatment group or a control group. Then, at intervals of 3 months, cervical swabs were obtained and analyzed by the polymerase chain reaction method for HPV type 16 DNA over the course of a year.

Mohanty and Lowe found that two years after treatment only three patients (4.6%) who received the therapy developed cervical warts. This corresponded to a failure rate of 8% (3:102). Moreover, in the untreated group, a total of five patients (20%) developed warts (3:103).

After 12 months only 3 patients (4.8%) developed clinical warts. This contrasted with 5 patients (20%) after 18 months in an untr
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