Synthesis Of A Chalcone Essay

Synthesis and Derivitazation of a Chalcone



Introduction

Chalcone is haved for this experiment by aldol reaction of aldehyde and an acetophenone. Chalcone is synthesized to other reactions such as isoxazole, chalcone dibromide, and chalcone oxide. In these synthesizing experiments filtration and recrystallization takes place. The filtration is through with(p) to separate the solvent from the sample. With increasing temperatures the solute can be fade out by a solvent during recrystallization.

Experimental section

Preparation of Chalcone

To prepare chalcone 2.1mL of NaOH in was dissolve in 40mL of water and about 25mL of neutral spirits was added in a 125mL Erlenmeyer flask as soon as pellets were dissolved. Then 0.080 mole of acetophenone was turned on(p) into the 125 mL flask, then(prenominal) place into an ice bath. At once 0.080 moles of bezaldehyde was added to the mixture and touched all the while temperature was kept between 20-30°C. A male plug was placed on the flask while the mixture was stir with stirrer for 11/2 hours. After the mixture had been stirred the flask was wrapped in foil and place inside(a) the freezer overnight. After the mixture had been frozen overnight and unfreeze it was then filtered on a Buchner Funnel and the flask was rinsed with ethanol and recrystallized.



To recrystallize, the crystals that were make afterward being filtered were redissolved in about 500mL of potent ethanol because of the 4-Chlorobenzaldehyde used, and it was placed in an ice bath. After the crystals were formed they were filtered on a Buchner Funnel, they were let dry over night, and were weighed after they had dried. Also the percent yield, and IR Spectral were collected.
Preparation of Isoxazole



hydroxyl amine was dissolved in 2.5mL of water in a 250mL Erlenmeyer flask. In a separate flask about 0.0125moles of chalcone was dissolved using about 500mL of ethanol because 4-Chlorobenzaldehyde was used in this experiment. This had to be done twice; the first...If you want to get a complete essay, order it on our website: Orderessay



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