Platelet Structure And Function

Platelet Structure and Function Platelets ar disklike anuclear cells that get up from megakaryocytes in the bone marrow, which shed their cytoplasm into thrombocyte size of it fragments afterward following a pattern of differentiation and maturation. The principal(prenominal) hormone that controls megakorocyte development is thrombopoietin. The life span of a thrombocyte in the circulation is 7-10 days. Circulating platelets in a resting state are discoid in shape and approximately 0.3-0.5µm in size. The expression platelet count in a well-informed individual is 140-400x109/l. Platelets have an important role in line of merchandise coagulation. When a watercraft is injured platelets immediately form a adulteress at the site of injury; this is called primary haemostasis. auxiliary hemostasis occurs simultaneously: Structure of blood platelets Platelets have a exceedingly specialised body structure: Figure 1 Shows the generalised structure of a platel et and organisation of the features to be discussed [pic] Platelet membrane The platelet membrane is vital to platelet function for 2 reasons: 1. It contains a number of glycoprotein receptors through which platelets pit with aggregating agents, inhibitors, coagulation instruments and consequently the vessel wall and each other. some of the important glycoproteins include GP1a and GP1b.

GP1a binds to collagen and GP1b binds to von Willebrands factor 2. It too contains phospholipids, which act as a get up for interaction with ad hoc components of coagulation biochemistry, much(prenominal) as factor II and factor X The surface connected open canalicular sytem (S COCS) is a net income of take a shit thro! ughout the interior of the platelet formed from the invaginations of the membrane. These channels cast up the surface area of platelet exposed to plasma. This bears a passage for molecules to reach deep within the platelet cytoplasm. They withal provide a route for extrusion of substances out of the platelet at one time it has been activated. The dense tubular system (DTS) is a...If you want to get round a full essay, order it on our website: OrderEssay.net

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